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Clinical Pharmacokinetics and Pharmacodynamics: Concepts and Applications, by Malcolm Rowland, Thomas N. Tozer PharmD PhD
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Formerly Clinical Pharmacokinetics: Concepts and Applications, this fully updated Fourth Edition has been retitled Clinical Pharmacokinetics and Pharmacodynamics: Concepts and Applications to reflect the increasing body of knowledge linking the two concepts that explain the relationship between drug administration and drug response. This revised edition also reflects the explosion in our understanding at the molecular and mechanistic levels of all the processes controlling the pharmacokinetics of drugs. The text is authored by two leading international experts on the clinical aspects of pharmacokinetics/pharmacodynamics and is widely considered one of the authoritative texts on the subject.
A companion website includes the full text online, plus interactive simulations for student practice using different pharmacokinetic/pharmacodynamic models and parameters.
- Sales Rank: #357622 in Books
- Brand: Brand: Lippincott Williams Wilkins
- Published on: 2010-01-28
- Original language: English
- Number of items: 1
- Dimensions: 9.90" h x 1.50" w x 7.20" l, 3.85 pounds
- Binding: Hardcover
- 864 pages
- Used Book in Good Condition
Review
-- "This textbook covers a tremendous range of topics important in pharmacokinetics and pharmacodynamics. No other textbook does this as effectively as the Rowland and Tozer text." -- "I believe this book is the best written text for bridging the gap between basic PK and clinical PK."
Most helpful customer reviews
30 of 30 people found the following review helpful.
Great book, the gold standard intro
By model man
This book is a very finely crafted comprehensive introduction to pharmacokinetics, with enough pharmacodynamics to give one context. If you are new to PK/PD and need to understand and work with the subject matter this is an EXCELLENT starting point and a fine reference. The prose is clear, the organization thoughtful, and the figures and diagrams are masterful - best in class. The authors are both renowned academics with extensive industrial experience. That background shines through in the thoughtful way that topics are motivated and explained. I found the questions useful and thought-provoking. Isn't it the case that the more iron one pumps in the gym, the stronger one is on the playing field?
One thing that I would add to this book (and most other PK books I've seen) would be a comprehensive listing of the different math models (one or two compartment, IV, or zero or first order input, etc), highlighting different uses (closed form solutions are easiest to use for parameter estimations, ODE formulations for repeat dosing, etc.) and their different parameterizations. This book contains some of this information (e.g. Table 19-1), but an appendix with this info would be useful. An additional improvement with great teaching utility might be an elementary modeling/estimation program for MS-Excel.
For those needing an overview of PK (e.g. a pharma executive responsible for a development program) without a lot of the details necessary for practitioners, a less-comprehensive book that is also very good is Peter Welling's "Pharmacokinetics". Gabriellson's and Weiner's book "PK and PD Data Analysis" has a more spotty overview of the basic subject matter, but does have descriptions of many techniques not found elsewhere. The latter book is "WinNonLin-centric" (WinNonLin is a program written by one of the authors) which may be what is wanted.
My favorite intro book and basic referencer for PK is definitely Rowland and Tozer. Bravo!
2 of 2 people found the following review helpful.
Best reference on PK
By Tyler Barbour
This excellent book (1980 edition) was my introduction to this topic. I have it in my bookshelf and I keep referring back to it. Without planning it, I've become the resident PK expert in my department thanks to this reference! Thank you Drs. Rowland and Tozer.
3 of 4 people found the following review helpful.
The Bible of Pharmcokinetics
By Richard Wolf Wong
"Clinical Pharmacokinetics: Concepts and Applications" (or better known as Rowland and Tozer) is a book filled with deep concepts and good explanations. It is the Bible of Pharmacokinetics. If there is a PK concept you want to look up, this book will be the first place you look for it. Before giving the review, let me introduce my background. I have a formal education in physical chemistry and analytical chemistry and am currently working in the field of pharma. I have currently read through half of this book. Although I have not completely finishing the book, I believe there is enough information to share.
The previous PK book I read was Concepts In Clinical Pharmacokinetics by Joseph T. Dipiro and it is a shorter and simpler book than Rowland and Tozer. While "Concepts In Clinical Pharmacokinetics" was a delight to read, it is on the simpler side and a lot of concepts are left unexplained. When I was reading it, there were often moment of "How did he get from this to that?" or "Where this comes from?", and I had to stop reading and tried to derive the equations. In contrast, Rowland and Tozer explain the principles of PK in great details and often from multiple angles, so that the readers can fully appreciate how the concepts are linked together, how PK theories apply and how PK impacts pharmacology research and the drug discovery. The exercises are challenging, but not impossible. Well, a few of them are nearly impossible, but most of them can be worked out (even for someone of my background).
I would love to give it a 4.5 stars, but that is not an option. I do see there are a few shortcomings in this book. Although it is very detailed, it can be too detailed for beginners, except for students who has more time. It is best to start off with a short and easy to read introductory book. Yes, Rowland and Tozer have explained many concepts in multiple ways and this is generally good, except when you are busy. Sometime, I just feel like: I get your point already. The Final and the real criticism is that the book can be a bit dry. Unlike "Concepts In Clinical Pharmacokinetics", this is not a book to be breezed through.
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